(Updates prices, adds sector details)
March 22 (Reuters) - Canada's main stock index fell on Monday, dragged down by weakness in energy and materials stocks, while government data showed the domestic wholesale trade most likely fell in February.
* The energy sector .SPTTEN dropped 1.2%, while the materials sector .GSPTTMT , which includes precious and base metals miners and fertilizer companies, lost 0.2%
* Canadian wholesale trade most likely fell by 0.4% in February from January on lower sales in the building materials and supplies, and machinery, equipment and supplies subsectors, Statistics Canada said in a flash estimate. At 9:37 a.m. ET (1337 GMT), the Toronto Stock Exchange's S&P/TSX composite index .GSPTSE was down 59.59 points, or 0.32%, at 18,794.41.
* Paper and packaging company Cascades Inc CAS.TO fell 7.4%, the most on the TSX, after brokerage CIBC downgraded the rating of the stock. The second-biggest decliner was Labrador Iron Ore Royalty Corp LIF.TO , down 3%, after RBC downgraded the rating of the miner's stock.
* The financials sector .SPTTFS slipped 0.6%. The industrials sector .GSPTTIN fell 0.8%.
* On the TSX, 93 issues were higher, while 124 issues declined for a 1.33-to-1 ratio to the downside, with 11.62 million shares traded.
* The largest percentage gainers on the TSX were miner Lithium Americas Corp LAC.TO , which jumped 3.9%, and advertising firm AcuityAds Holdings Inc AT.TO , which rose 3.3%.
* The most heavily traded shares by volume were Bombardier Inc BBDb.TO , Fortune Minerals Limited FT.TO and Supreme Cannabis Company Inc FIRE.TO .
* The TSX posted one new 52-week highs and no new lows.
* Across all Canadian issues there were 19 new 52-week highs and one new low, with a total volume of 26.41 million shares.