Statistics Canada says wholesale sales fell 0.8 per cent to $62.8 billion in February.
The agency says it was the largest downward move and the second monthly drop since September 2017.
Sales fell in four of the seven sub-sectors tracked, representing 64 per cent of total wholesale sales.
In volume terms, wholesale sales fell 0.9 per cent.
The miscellaneous sub-sector posted the largest drop in dollar terms in February as it fell 3.7 per cent to $7.7 billion. Sales in the motor vehicle and parts sub-sector fell 2.1 per cent to $11.3 billion.
Meanwhile, sales in the personal and household goods sub-sector rose 0.8 per cent to $8.7 billion.
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