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C4 Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops novel therapeutic candidates to degrade disease-causing proteins for the treatment of cancer, neurodegenerative conditions, and other diseases. Its lead product candidate is CFT7455, an orally bioavailable MonoDAC degrader of protein that is in Phase 1/2 trial targeting IKZF1 and IKZF3 for multiple myeloma and non-Hodgkin lymphomas, including peripheral T-cell lymphoma and mantle cell lymphoma, currently under Phase 1/2 clinical trials. The company is also developing CFT1946, an orally bioavailable BiDAC degrader targeting V600X mutant BRAF to treat melanoma, non-small cell lung cancer (NSCLC), colorectal cancer, and other solid malignancies, currently under Phase 1/2 clinical trials; and CFT8919, an orally bioavailable, allosteric, and mutant-selective BiDAC degrader of epidermal growth factor receptor, or EGFR, with an L858R mutation in NSCLC. It has strategic collaborations with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc.; Biogen MA, Inc.; Betta Pharmaceuticals, Co., Ltd.; and Merck Sharp & Dohme, LLC, as well as Calico Life Sciences LLC. The company was incorporated in 2015 and is headquartered in Watertown, Massachusetts.
Name | Age | Since | Title |
---|---|---|---|
Andrew J. Hirsch | 51 | 2020 | CEO, President & Director |
Kenneth C. Anderson | 71 | 2015 | Co-Founder, Independent Director & Member of Scientific Advisory Board |
Donna Roy Grogan | 66 | 2022 | Independent Director |
Laura Bessen | - | 2022 | Independent Director |
Bruce L. Downey | 76 | 2015 | Chairman & Lead Independent Director |
Nathanael S. Gray | - | 2016 | Co-Founder & Member of Scientific Advisory Board |
Christopher J. Kirk | 50 | 2016 | Member of Scientific Advisory Board |
Glenn Russell Dubin | 66 | 2021 | Independent Director |
Ross L. Levine | 51 | 2017 | Member of Scientific Advisory Board |
Randi Isaacs | 67 | - | Member of Clinical Advisory Board |
Scott A. Armstrong | - | 2017 | Member of Scientific Advisory Board |
Christopher J. Bowden | 62 | - | Member of Clinical Advisory Board |
Hagop Youssoufian | 66 | 2023 | Member of Clinical Advisory Board |
Malcolm S. Salter | 83 | 2015 | Independent Director |
Utpal Koppikar | 52 | 2022 | Independent Director |
Beni B. Wolf | - | - | Member of Clinical Advisory Board |
Ryan B. Corcoran | - | 2019 | Member of Scientific Advisory Board |
Owen P. Hughes | 49 | 2023 | Independent Director |
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