- Investing.com
Lyell Immunopharma, Inc., a clinical-stage cell therapy company, develops chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. The company’s lead product candidate include rondecabtagene autoleucel, an autologous dual-targeting CD19/CD20 CAR T-cell therapy in development, which is in pivotal PiNACLE trial in the 3L+ setting and in a Phase 1/2 clinical trial in the 2L setting, as well as a second pivotal trial, PiNACLE-H2H, which is a Phase 3 head-to-head CAR T cell therapy randomized controlled trial of ronde-cel for LBCL in the 2L setting for the treatment of large B-cell lymphoma; and LYL273, a GCC-targeted CAR T-cell product candidate enhanced with CD19 CAR expression and controlled cytokine release designed to improve CAR T-cell expansion, immune cell infiltration, and cancer cell killing in the hostile solid tumor microenvironment, which is in Phase 1 clinical trial for the treatment of refractory metastatic colorectal cancer. The company develops therapies using various approaches, such as c-Jun overexpression and NR4A3 gene knockout, to endow functional resistance to exhaustion; Epi-R to generate population of stem-like T cells with reduced exhaustion and improved proliferation and antitumor activity; and CD62L positive enrichment to generate CAR T cells with enhanced antitumor activity. Lyell Immunopharma, Inc. was incorporated in 2018 and is headquartered in South San Francisco, California.
Metrics to compare | LYEL | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipLYELPeersSector | |
|---|---|---|---|---|
P/E Ratio | −1.7x | −3.9x | −0.5x | |
PEG Ratio | 0.05 | −0.10 | 0.00 | |
Price/Book | 1.7x | 2.7x | 2.6x | |
Price / LTM Sales | 13,693.5x | 7.1x | 3.1x | |
Upside (Analyst Target) | 29.4% | 330.6% | 57.5% | |
Fair Value Upside | Unlock | 18.8% | 8.6% | Unlock |