Sarepta Therapeutics, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery and development of RNA-targeted therapeutics, siRNA platform, gene therapy, and other genetic therapeutic modalities for the treatment of rare diseases. It offers EXONDYS 51 for the treatment of Duchenne in patients who have a confirmed mutation of the dystrophin gene that is amenable to exon 51 skipping; VYONDYS 53 for the treatment of Duchenne in patients who have a confirmed mutation of the dystrophin gene that is amenable to exon 53 skipping; AMONDYS 45 for the treatment of Duchenne in patients who have a confirmed mutation of the dystrophin gene that is amenable to exon 45 skipping; and ELEVIDYS, an AAV-based gene therapy, which is contraindicated in patients with any deletion in exon 8 and/or exon 9 in the Duchenne gene. The company also develops SRP-9003, a gene therapy program for the treatment of LGMD2E; SRP-1001 to selectively target and knockdown DUX4 using RNAi in Phase 1/2a clinical trials; and SRP-1003 for reduction of expression of the DMPK gene in Phase 1/2a clinical trials. It has collaboration and license agreements with F. Hoffman-La Roche Ltd; Arrowhead Pharmaceuticals, Inc.; University of Western Australia; Nationwide Children’s Hospital; Hansa Biopharma; and Duke University. The company was incorporated in 1980 and is headquartered in Cambridge, Massachusetts.
Gene Therapy Setbacks | Delve into Sarepta's challenges with Elevidys, including safety concerns and regulatory hurdles, impacting its market position and financial outlook |
Pipeline Potential | Explore Sarepta's diverse pipeline beyond DMD, including promising treatments for LGMD and other rare neuromuscular diseases |
Market Dynamics | Uncover Sarepta's competitive landscape, strategic partnerships, and potential threats from emerging therapies in the muscular dystrophy market |
Financial Trajectory | Analyst price targets range from $21 to $210, reflecting diverse views on Sarepta's future prospects amid current challenges and long-term growth potential |
Metrics to compare | SRPT | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipSRPTPeersSector | |
|---|---|---|---|---|
P/E Ratio | −2.3x | 18.9x | −0.5x | |
PEG Ratio | 0.01 | 0.01 | 0.00 | |
Price/Book | 1.5x | 1.3x | 2.6x | |
Price / LTM Sales | 0.8x | 2.0x | 3.2x | |
Upside (Analyst Target) | 17.1% | 26.5% | 51.4% | |
Fair Value Upside | Unlock | 8.3% | 8.5% | Unlock |